Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance
نویسندگان
چکیده
منابع مشابه
Reproducibility of GFR measured by chromium-51-EDTA and iohexol.
We read with interest the article published by Bird et al about the reproducibility of measured GFR by iohexol and Cr-51-EDTA [ 1 ]. We would like to make one comment and to share our own results on this fundamental (although understudied) topic. As we already pointed out in a NDT editorial, we share the same reserves about the opportunity to index glomerular filtration rate (GFR) with body sur...
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Sir, In the interesting article ‘Estimating glomerular filtration in the general population: the second Health Survey of Nord-Trondelag (HUNT II)’ by Hallan et al. [1], attention is drawn to the increasing documentation of ‘large underestimation of glomerular filtration rate (GFR) in older subjects using the Cockcroft–Gault formula’. The authors present a new population-based GFR formula and po...
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There is no simple method to measure glomerular filtration rate (GFR) in swine, an 15 established model to study renal disease. We developed a protocol to measure GFR in conscious 16 swine with the plasma clearance of iohexol. We used two groups: testing and validation, of 8 17 animals each. Ten milliliters of iohexol (6.47 g) were injected by the marginal auricular vein and 18 blood samples (3...
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To the Editor: Iohexol is regarded as an accurate filtration marker for measuring GFR. Recently, Soveri et al concluded that plasma clearance of iohexol could be considered a valid alternative to the gold standard, urinary clearance of inulin. Because inulin urinary clearance is cumbersome and costly, iohexol and iothalamate clearance have become popular in Europe and the United States, respect...
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Clinical assessment of kidney function is central to the practice of medicine. GFR is widely accepted as the best index of kidney function in health and disease, and accurate values are required for optimal decision making. Estimated GFR based on serum creatinine is now widely reported by clinical laboratories, and in most circumstances, estimated GFR is sufficient for clinical decision making....
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2020
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2019.11.012